Cabergolina Hiperprolactinemia Doença de Parkinson Tratar Dicloridrato de Pramipexol
Cabergoline 98% Min
Cabergoline
Nome do Produto: Cabergoline
Outro nome: 6-alil-n-[3-(dimetilamino)propil]-n-(etilcarbamoil)ergolina-8-carboxamida; Cabareiro; Dostine
CAS: 81409-90-7
MF: C26H37N5O2
MW: 451.6
Propriedades quimicas: Sólido Cristalino Branco.
Usos: Um agonista do receptor D2 da dopamina. receptor stimulant
Definition : Uma N-acilureia que é (8R)-ergolina-8-carboxamida em que o hidrogênio ligado ao nitrogênio da piperidina (posição 6) is substituted by an allyl group and the hydrogens attached to the carboxamide nitrogen are substit ted by a 3-(dimetilamino)propyl group and an N-ethylcarbamoyl group. A dopamine D2 receptor agonist, cabergoline is used in the management of Parkinson’s disease and of disorders associated with hyperprolactinaemia.
Atividade biológica: Selective D 2 -like dopamine receptor agonist (K i values are 0.7, 1.5, 9.0 e 165 nM for D 2 , D 3 , D 4 and D 5 receptors respectively) that also displays high affinity for several serotonin receptor subtypes (K i = 1.2-20.0 nM for 5-HT 1A , 5-HT 1D , 5-HT 2A and 5-HT 2B ). Inhibits secretion of prolactin and growth hormone and reverses levodopa-induced dyskinesias in Parkinsonian monkeys.
