Cabergolina Hiperprolactinemia Enfermedad de Parkinson Tratar el diclorhidrato de pramipexol
cabergolina 98% Min
cabergolina
nombre del producto: cabergolina
Otro nombre: 6-alilo-n-[3-(dimetilamino)propilo]-norte-(etilcarbamoilo)ergolina-8-carboxamida; Cabáser; Dostine
CAS: 81409-90-7
FM: C26H37N5O2
megavatio: 451.6
Propiedades químicas: Sólido cristalino blanco.
Usos: Un agonista del receptor de dopamina D2. receptor stimulant
Definition : Una N-acilurea que es (8R)-ergolina-8-carboxamida en la que el hidrógeno se une al nitrógeno de piperidina (posición 6) is substituted by an allyl group and the hydrogens attached to the carboxamide nitrogen are substit ted by a 3-(dimetilamino)propyl group and an N-ethylcarbamoyl group. A dopamine D2 receptor agonist, cabergoline is used in the management of Parkinson’s disease and of disorders associated with hyperprolactinaemia.
Actividad biológica: Selective D 2 -like dopamine receptor agonist (K i values are 0.7, 1.5, 9.0 y 165 nM for D 2 , D 3 , D 4 and D 5 receptors respectively) that also displays high affinity for several serotonin receptor subtypes (K i = 1.2-20.0 nM for 5-HT 1A , 5-HT 1D , 5-HT 2A and 5-HT 2B ). Inhibits secretion of prolactin and growth hormone and reverses levodopa-induced dyskinesias in Parkinsonian monkeys.
